Major Ingredients

Each film coated tablet contains Imatinib 400 mg as Imatinib Mesylate INN.

Major Functionality

Newly Diagnosed Philadelphia Positive Chronic Myeloid Leukemia (Ph+ CML): Metanib is indicated for the treatment of newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase. Ph+ CML in Blast Crisis (BC), Accelerated Phase (AP) or Chronic Phase (CP) after Interferon-alpha (IFN) Therapy: Metanib is indicated for the treatment of patients with Philadelphia chromosome positive chronic myeloid leukemia in blast crisis, accelerated phase, or in chronic phase after failure of interferon-alpha therapy. Adult Patients with Ph+ Acute Lymphoblastic Leukemia (ALL): Metanib is indicated for the treatment of adult patients with relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL). Pediatric Patients with Ph+ Acute Lymphoblastic Leukemia (ALL): Metanib is indicated for the treatment of pediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) in combination with chemotherapy. Myelodysplastic/Myeloproliferative Diseases (MDS/MPD): Metanib is indicated for the treatment of adult patients with myelodysplastic/myeloproliferative diseases associated with PDGFR (platelet-derived growth factor receptor) gene re-arrangements as determined with an FDA-approved test. Aggressive Systemic Mastocytosis (ASM): Metanib is indicated for the treatment of adult patients with aggressive systemic mastocytosis without the D816V c-Kit mutation as determined with an FDA-approved test. Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL): Metanib is indicated for the treatment of adult patients with hypereosinophilic syndrome and/or chronic eosinophilic leukemia who have the FIP1L1-PDGFRα fusion kinase (mutational analysis or FISH demonstration of CHIC2 allele deletion) and for patients with HES and/or CEL who are FIP1L1-PDGFRα fusion kinase negative or unknown. Dermatofibrosarcoma Protuber

Manufacture Information

Drug International Limited was incorporated under the Registrar of Joint Stock Companies in 1974 as a Private Limited Company. The company commenced formulation and production in 1983 and emerged as a pioneer in Bangladesh for adding a state of the art oral solid dosage plant. Since inception, Drug International Limited's primary objective has been to meet guidelines provided by major global regulatory bodies such as the World Health Organization Good Manufacturing Practices (WHO cGMP) guidelines.